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Pretreatment Serum Amyloid A and C-reactive Protein Comparing with Epstein-Barr Virus DNA as Prognostic Indicators in Patients with Nasopharyngeal Carcinoma: A Prospective Study.
- Source :
-
Cancer research and treatment [Cancer Res Treat] 2018 Jul; Vol. 50 (3), pp. 701-711. Date of Electronic Publication: 2017 Jul 14. - Publication Year :
- 2018
-
Abstract
- Purpose: The measuring Epstein-Barr virus (EBV) DNA is an important predictor of nasopharyngeal carcinoma (NPC). This study evaluated the predictive value of pretreatment serum amyloid A (SAA) and C-reactive protein (CRP) comparing with EBV DNA in patients with NPC.<br />Materials and Methods: In an observational study of 419 non-metastatic NPC patients, we prospectively evaluated the prognostic effects of pretreatment SAA, CRP, and EBV DNA on survival. The primary endpoint was progress-free survival (PFS).<br />Results: The median level of SAA and CRP was 4.28 mg/L and 1.88 mg/L, respectively. For the highSAA group (&gt; 4.28 mg/L) versus the low-SAA (≤ 4.28 mg/L) group and the high-CRP group (&gt; 1.88 mg/L) versus the low-CRP (≤ 1.88 mg/L) group, the 5-year PFS was 64.5% versus 73.1% (p=0.013) and 65.2% versus 73.3% (p=0.064), respectively. EBV DNA detection showed a superior predictive result, the 5-year PFS in the EBV DNA ≥ 1,500 copies/mL group was obviously different than the EBV DNA &lt; 1,500 copies/mL group (62.2% versus 77.8%, p &lt; 0.001). Multifactorial Cox regression analysis confirmed that in the PFS, the independent prognostic factors were including EBV DNA (hazard ratio [HR], 1.788; p=0.009), tumour stage (HR, 1.903; p=0.021), and node stage (HR, 1.498; p=0.049), but the SAA and CRP were not included in the independent prognostic factors.<br />Conclusion: The results of SAA and CRP had a certain relationship with the prognosis of NPC, and the prognosis of patients with high level of SAA and CRP were poor. However, the predictive ability of SAA and CRP was lower than that of EBV DNA.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma metabolism
Carcinoma pathology
Epstein-Barr Virus Infections pathology
Epstein-Barr Virus Infections virology
Female
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms metabolism
Nasopharyngeal Neoplasms pathology
Neoplasm Staging
Prognosis
Prospective Studies
Young Adult
C-Reactive Protein metabolism
Carcinoma virology
DNA, Viral genetics
Epstein-Barr Virus Infections metabolism
Herpesvirus 4, Human genetics
Nasopharyngeal Neoplasms virology
Serum Amyloid A Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2005-9256
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer research and treatment
- Publication Type :
- Academic Journal
- Accession number :
- 28707462
- Full Text :
- https://doi.org/10.4143/crt.2017.180