Back to Search
Start Over
Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 2017 Oct 15; Vol. 142, pp. 133-144. Date of Electronic Publication: 2017 Jul 13. - Publication Year :
- 2017
-
Abstract
- Recently, microsomal prostaglandin E synthase 1 (mPGES-1) has attracted much attention from pharmacologists as a promising strategy and an attractive target for treating various types of diseases including rheumatoid arthritis (RA), which could preserve the anti-inflammatory effect while reducing the adverse effects often occur during administration of non-steroidal anti-inflammatory drugs (NSAIDs). Here, we report that sinomenine (SIN) decreased prostaglandin (PG)E <subscript>2</subscript> levels without affecting prostacyclin (PG)I <subscript>2</subscript> and thromboxane (TX)A <subscript>2</subscript> synthesis via selective inhibiting mPGES-1 expression, a possible reason of low risk of cardiovascular event compared with NSAIDs. In addition, mPGES-1 protein expression was down-regulated by SIN treatment in the inflamed paw tissues both in carrageenan-induced edema model in rats and the collagen-II induced arthritis (CIA) model in DBA mice. More interestingly, SIN suppressed the last step of mPGES-1 gene expression by decreasing the DNA binding ability of NF-κB, paving a new way for drug discovery.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- A549 Cells
Animals
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Anti-Inflammatory Agents, Non-Steroidal isolation & purification
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Arthritis, Experimental immunology
Cell Culture Techniques
Cell Survival drug effects
Edema immunology
Female
Macrophages, Peritoneal drug effects
Male
Mice, Inbred DBA
Morphinans adverse effects
Morphinans isolation & purification
Morphinans pharmacology
Rats, Sprague-Dawley
Transfection
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Arthritis, Experimental drug therapy
Edema drug therapy
Gene Expression drug effects
Morphinans therapeutic use
Prostaglandin-E Synthases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2968
- Volume :
- 142
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28711625
- Full Text :
- https://doi.org/10.1016/j.bcp.2017.07.010