Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis.

Authors :: Slominski AT
Brożyna AA
Tuckey RC
Source :: The Journal of investigative dermatology [J Invest Dermatol] 2017 Aug; Vol. 137 (8), pp. 1609-1611.
Publication Year :: 2017
Abstract: Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.<br /> (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)

Subjects :: Administration, Cutaneous
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents pharmacokinetics
Humans
Hydrocortisone administration & dosage
Signal Transduction
Skin drug effects
Skin pathology
Hydrocortisone pharmacokinetics
Psoriasis drug therapy
Psoriasis metabolism
Psoriasis pathology
Receptors, Glucocorticoid metabolism
Skin metabolism

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