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Silver-Catalyzed Tandem C≡C Bond Hydroazidation/Radical Addition/Cyclization of Biphenyl Acetylene: One-Pot Synthesis of 6-Methyl Sulfonylated Phenanthridines.
- Source :
-
Organic letters [Org Lett] 2017 Aug 04; Vol. 19 (15), pp. 4026-4029. Date of Electronic Publication: 2017 Jul 24. - Publication Year :
- 2017
-
Abstract
- A silver-catalyzed tandem carbon-carbon triple bond hydroazidation, radical addition, and cyclization of biphenyl acetylene is described under mild conditions, leading to the formation of 6-methyl sulfonylated phenanthridines in good yields. In this novel cascade reaction, most of the atoms are incorporated into the product without cleavage of the C≡C bond. Mechanistic studies suggest the reaction should proceed through an iminyl radical reactive intermediate.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28737404
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b01771