Back to Search
Start Over
An [ 18 F]-Positron-Emitting, Fluorescent, Cerebrospinal Fluid Probe for Imaging Damage to the Brain and Spine.
- Source :
-
Theranostics [Theranostics] 2017 Jun 15; Vol. 7 (9), pp. 2377-2391. Date of Electronic Publication: 2017 Jun 15 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Fluorescein is modified to bear <superscript>18</superscript> F so that it can act as both a positron emitter, and a fluorophore, allowing detection by positron emission tomography (PET), scintillation, and fluorescent imaging (FL). [ <superscript>18</superscript> F]- 2 is injected into the intrathecal space of rats and used to observe the cerebrospinal fluid (CSF) that bathes the brain and spine. Injury in three different applications is visualized with [ <superscript>18</superscript> F]- 2 : 1) detection of a 0.7 mm paranasal-sinus CSF leak (CSFL); 2) detection of 0.5 mm puncture damage to the thoracic spine (acute spinal cord injury); and 3) detection of intracerebral hemorrhage/edema because of traumatic brain injury. In all models, the location of injury is visualized with [ <superscript>18</superscript> F]- 2 at high resolution. [ <superscript>18</superscript> F]- 2 PET imaging may be a superior alternative to current clinical contrast myelography and <superscript>131</superscript> I, <superscript>111</superscript> In or <superscript>99m</superscript> Tc radionuclide cisternography. Like fluorescein, [ <superscript>18</superscript> F]- 2 may also have other uses in diagnostic or fluorescence guided medicine.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
- Subjects :
- Animals
Brain Injuries pathology
Injections, Spinal
Rats
Spinal Injuries pathology
Brain Injuries diagnostic imaging
Cerebrospinal Fluid chemistry
Fluorescein administration & dosage
Fluorine Radioisotopes administration & dosage
Optical Imaging methods
Positron-Emission Tomography methods
Spinal Injuries diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1838-7640
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Theranostics
- Publication Type :
- Academic Journal
- Accession number :
- 28744321
- Full Text :
- https://doi.org/10.7150/thno.19408