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Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Jul; Vol. 163 (3), pp. 389-393. Date of Electronic Publication: 2017 Jul 25. - Publication Year :
- 2017
-
Abstract
- EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats. The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia, a decrease in proteinuria and sodium excretion, prevention of critical decrease in activities of antioxidant enzymes, suppression of LPO, and normalization of energy supply to kidneys cells. Our findings confirm the prospects of further studies of the nephroprotective properties of peptide EDL in various pathologies of the kidneys.
- Subjects :
- Acute Kidney Injury blood
Acute Kidney Injury chemically induced
Acute Kidney Injury physiopathology
Animals
Animals, Outbred Strains
Antioxidants chemical synthesis
Azotemia blood
Azotemia physiopathology
Azotemia prevention & control
Gentamicins
Kidney Function Tests
Lipid Peroxidation drug effects
Oliguria blood
Oliguria physiopathology
Oliguria prevention & control
Peptides chemical synthesis
Protective Agents chemical synthesis
Proteinuria blood
Proteinuria physiopathology
Proteinuria prevention & control
Rats
Reperfusion Injury blood
Reperfusion Injury physiopathology
Acute Kidney Injury prevention & control
Antioxidants pharmacology
Peptides pharmacology
Protective Agents pharmacology
Reperfusion Injury prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 163
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28744634
- Full Text :
- https://doi.org/10.1007/s10517-017-3811-1