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Development and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2017 Dec 20; Vol. 35 (36), pp. 4057-4065. Date of Electronic Publication: 2017 Aug 04. - Publication Year :
- 2017
-
Abstract
- Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). Methods To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522). Nomograms were created from Cox models and internally validated by use of bootstrap and cross-validation. Model discrimination was measured by calibration plots and the concordance index. Nomograms were externally validated in a cohort of 153 patients with OPSCC randomly assigned to a third trial, NRG Oncology RTOG 9003. Results Both models included age, Zubrod performance status, pack-years, education, p16 status, and T and N stage; the OS model also included anemia and age × pack-years interaction; and the PFS model also included marital status, weight loss, and p16 × Zubrod interaction. Predictions correlated well with observed 2-year and 5-year outcomes. The uncorrected concordance index was 0.76 (95% CI, 0.72 to 0.80) for OS and 0.70 (95% CI, 0.66 to 0.74) for PFS, and bias-corrected indices were similar. In the validation set, OS and PFS models were well calibrated, and OS and PFS were significantly different across tertiles of nomogram scores (log-rank P = .003;< .001). Conclusion The validated nomograms provided useful prediction of OS and PFS for patients with OPSCC treated with primary radiation-based therapy.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Chemoradiotherapy
Cohort Studies
Disease-Free Survival
Female
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms radiotherapy
Humans
Male
Middle Aged
Organoplatinum Compounds administration & dosage
Oropharyngeal Neoplasms diagnosis
Oropharyngeal Neoplasms drug therapy
Oropharyngeal Neoplasms radiotherapy
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Randomized Controlled Trials as Topic
Squamous Cell Carcinoma of Head and Neck
Survival Rate
Carcinoma, Squamous Cell mortality
Head and Neck Neoplasms mortality
Nomograms
Oropharyngeal Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1527-7755
- Volume :
- 35
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28777690
- Full Text :
- https://doi.org/10.1200/JCO.2016.72.0748