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Outcome of percutaneous coronary intervention with the Absorb bioresorbable scaffold: data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR).
- Source :
-
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2017 Dec 20; Vol. 13 (11), pp. 1303-1310. - Publication Year :
- 2017
-
Abstract
- Aims: Randomised trials indicate higher rates of stent thrombosis (ST) and target lesion failure (TLF) after percutaneous coronary intervention (PCI) with the Absorb bioresorbable scaffold (BRS) compared with modern drug-eluting stents (DES). We aimed to investigate the outcome of all Swedish patients treated with the Absorb BRS.<br />Methods and Results: The Absorb BRS (n=810) was compared with commonly used modern DES (n=67,909). The main outcome measure was definite ST; mean follow-up was two years. Despite being implanted in a younger, lower-risk population compared with modern DES, the Absorb BRS was associated with a higher crude incidence of definite ST at stent level: 1.5 vs. 0.6%, hazard ratio (HR) 2.38 (95% confidence interval [CI]: 1.34-4.23), adjusted HR 4.34 (95% CI: 2.37-7.94); p<0.001. The patient level adjusted HR was 4.44 (95% CI: 2.25-8.77). Rates of in-stent restenosis were similar for BRS and DES. Non-compliance with dual antiplatelet therapy (DAPT) guidelines was noted in six out of 12 BRS ST events. Three very late ST events occurred with the Absorb BRS.<br />Conclusions: In this real-world observational study, the Absorb BRS was associated with a significantly higher risk of definite ST compared with modern DES. Non-compliance with DAPT guideline recommendations was common among Absorb definite ST events.
- Subjects :
- Aged
Coronary Restenosis diagnostic imaging
Coronary Restenosis mortality
Coronary Thrombosis diagnostic imaging
Coronary Thrombosis mortality
Female
Humans
Incidence
Kaplan-Meier Estimate
Male
Medication Adherence
Middle Aged
Myocardial Ischemia diagnostic imaging
Myocardial Ischemia mortality
Percutaneous Coronary Intervention adverse effects
Percutaneous Coronary Intervention mortality
Platelet Aggregation Inhibitors administration & dosage
Proportional Hazards Models
Prosthesis Design
Registries
Retrospective Studies
Risk Factors
Sweden epidemiology
Time Factors
Treatment Outcome
Absorbable Implants
Coronary Angiography
Drug-Eluting Stents
Myocardial Ischemia therapy
Percutaneous Coronary Intervention instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1969-6213
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 28781242
- Full Text :
- https://doi.org/10.4244/EIJ-D-17-00458