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Treatment with PTEN-Long protein inhibits hepatitis C virus replication.
- Source :
-
Virology [Virology] 2017 Nov; Vol. 511, pp. 1-8. Date of Electronic Publication: 2017 Aug 04. - Publication Year :
- 2017
-
Abstract
- Hepatitis C virus (HCV) infection is a confirmed risk factor for hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) possesses tumor suppression function that is frequently defective in HCC tumors. PTEN-Long, a translation isoform of PTEN, functions in a cell non-autonomous manner. In this study, we demonstrated that intracellular overexpression of PTEN-Long inhibits HCV replication. More importantly, we showed that treatment with extracellular PTEN-Long protein inhibits HCV replication in a dose-dependent manner. Furthermore, we showed that PTEN-Long interacts with HCV core protein and this interaction is required for HCV replication inhibition by PTEN-Long. In summary, we demonstrated, for the first time, that PTEN-Long protein, an isoform of the canonical PTEN and in the form of extracellular protein treatment, inhibits HCV replication. Our study offers an opportunity for developing additional anti-HCV agents.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Antiviral Agents pharmacology
Carcinoma, Hepatocellular virology
Cell Line, Tumor
Humans
Liver Neoplasms virology
PTEN Phosphohydrolase genetics
Recombinant Proteins genetics
Recombinant Proteins metabolism
Viral Core Proteins metabolism
Gene Expression
Hepacivirus physiology
PTEN Phosphohydrolase metabolism
Virus Replication
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 511
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 28783500
- Full Text :
- https://doi.org/10.1016/j.virol.2017.08.002