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Bioactive mesoporous silica nanostructures with anti-microbial and anti-biofilm properties.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2017 Oct 05; Vol. 531 (1), pp. 35-46. Date of Electronic Publication: 2017 Aug 07. - Publication Year :
- 2017
-
Abstract
- The increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. Nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. Delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. Herein we report the development of SiO <subscript>2</subscript> mesoporous nanosystems loaded with eucalyptus (EUC), orange (ORA), and cinnamon (CIN) essential oils. These systems were characterized with respect to morphology (using scanning electron microscopy, SEM, and transmission electron microscopy, TEM), porosity (by BET and TEM analysis), chemical composition (by X-ray diffraction, XRD, and Fourier transform infrared spectrometry, FTIR) and loading capacity (by thermogravimetric analysis, TGA). The anti-bacterial and anti-adherence effects were tested against clinically relevant microbial species (Staphylococcus aureus ATCC 25923; Escherichia coli ATCC 25922; and Candida albicans ATCC 10231), while the biocompatibility was evaluated by in vitro tests with L929 mouse fibroblast cells.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Candida albicans drug effects
Cell Line
Cross Infection
Escherichia coli drug effects
Fibroblasts drug effects
Mice
Oils, Volatile pharmacology
Staphylococcus aureus drug effects
X-Ray Diffraction
Anti-Infective Agents chemistry
Biofilms drug effects
Drug Delivery Systems
Nanostructures chemistry
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 531
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 28797969
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2017.08.062