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The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2017 Aug 09; Vol. 22 (2), pp. 232-245. - Publication Year :
- 2017
-
Abstract
- Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 28799908
- Full Text :
- https://doi.org/10.1016/j.chom.2017.07.003