Back to Search
Start Over
Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial.
- Source :
-
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2017 Aug 15; Vol. 12 (1), pp. 124. Date of Electronic Publication: 2017 Aug 15. - Publication Year :
- 2017
-
Abstract
- Background: Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture.<br />Methods: A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3.<br />Results: On postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 ± 202.14 mL vs. 359.35 ± 290.12 mL; P < 0.05) and total blood loss volume (279.35 ± 209.11 mL vs. 417.89 ± 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively.<br />Conclusion: TXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA. (Registration number: ChiCTR-INR-16008134).
- Subjects :
- Aged
Aged, 80 and over
Female
Fracture Fixation, Internal methods
Fracture Fixation, Internal statistics & numerical data
Humans
Male
Postoperative Hemorrhage etiology
Prospective Studies
Antifibrinolytic Agents therapeutic use
Fracture Fixation, Internal adverse effects
Hip Fractures surgery
Postoperative Hemorrhage prevention & control
Tranexamic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1749-799X
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic surgery and research
- Publication Type :
- Academic Journal
- Accession number :
- 28810918
- Full Text :
- https://doi.org/10.1186/s13018-017-0625-9