Multiple emulsions as effective platforms for controlled anti-cancer drug delivery.

Authors :: Dluska E
Markowska-Radomska A
Metera A
Tudek B
Kosicki K
Source :: Nanomedicine (London, England) [Nanomedicine (Lond)] 2017 Sep; Vol. 12 (18), pp. 2183-2197. Date of Electronic Publication: 2017 Aug 18.
Publication Year :: 2017
Abstract: Aim: Developing pH-responsive multiple emulsion platforms for effective glioblastoma multiforme therapy with reduced toxicity, a drug release study and modeling.<br />Materials & Methods: Cancer cell line: U87 MG, multiple emulsions with pH-responsive biopolymer and encapsulated doxorubicin (DOX); preparation of multiple emulsions in a Couette-Taylor flow biocontactor, in vitro release study of DOX (fluorescence intensity analysis), in vitro cytotoxicity study (alamarBlue cell viability assay) and numerical simulation of DOX release rates.<br />Results: The multiple emulsions offered a high DOX encapsulation efficiency (97.4 ± 1%) and pH modulated release rates of a drug. Multiple emulsions with a low concentration of DOX (0.02 μM) exhibited broadly advanced cell (U87 MG) cytotoxicity than free DOX solution used at the same concentration.<br />Conclusion: Emulsion platforms could be explored for potential delivery of chemotherapeutics in glioblastoma multiforme therapy.

Subjects :: Brain Neoplasms drug therapy
Cell Line, Tumor
Cell Survival
Computer Simulation
Drug Delivery Systems
Drug Liberation
Glioblastoma drug therapy
Humans
Hydrogen-Ion Concentration
Particle Size
Surface Properties
Antineoplastic Agents administration & dosage
Antineoplastic Agents chemistry
Doxorubicin administration & dosage
Doxorubicin chemistry
Emulsions chemistry

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