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Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans: The Jackson Heart Study.
- Source :
-
JACC. Heart failure [JACC Heart Fail] 2017 Sep; Vol. 5 (9), pp. 642-651. Date of Electronic Publication: 2017 Aug 16. - Publication Year :
- 2017
-
Abstract
- Objectives: This study examined the association of aldosterone and plasma renin activity (PRA) with incident cardiovascular disease (CVD), using a composite endpoint of coronary heart disease, stroke, and/or heart failure and mortality among African Americans in the Jackson Heart Study.<br />Background: There is a paucity of data for the association of aldosterone and PRA with incident CVD or all-cause mortality among community-dwelling African Americans.<br />Methods: A total of 4,985 African American adults, 21 to 94 years of age, were followed for 12 years. Aldosterone, PRA, and cardiovascular risk factors were collected at baseline (from 2000 to 2004). Incident events included coronary heart disease and stroke (assessed from 2000 to 2011) and heart failure (assessed from 2005 to 2011). Cox models were used to estimate hazard ratios (HRs) for incident CVD and mortality, adjusting for age, sex, education, occupation, current smoking, physical activity, dietary intake, and body mass index.<br />Results: Among 4,160 participants without prevalent CVD over a median follow-up of 7 years, there were 322 incident CVD cases. In adjusted analyses, each 1-U SD increase in log-aldosterone and log-PRA were associated with HR of 1.26 (95% confidence intervals [CI]: 1.14 to 1.40) and 1.16 (95% CI: 1.02 to 1.33) for incident CVD, respectively. Over a median of 8 years, 513 deaths occurred among 4,985 participants. In adjusted analyses, each 1-U SD increase in log-aldosterone and log-PRA were associated with HRs of 1.13 (95% CI: 1.04 to 1.23) and 1.12 (95% CI: 1.01 to 1.24) for mortality, respectively.<br />Conclusions: Elevated aldosterone and PRA may play a significant role in the development of CVD and all-cause mortality among African Americans.<br /> (Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Black or African American ethnology
Aged
Aged, 80 and over
Aldosterone metabolism
Body Mass Index
Cardiovascular Diseases ethnology
Cause of Death
Coronary Disease ethnology
Coronary Disease mortality
Female
Humans
Incidence
Male
Middle Aged
Myocardial Infarction ethnology
Myocardial Infarction mortality
Prospective Studies
Renin metabolism
Risk Factors
Stroke ethnology
Stroke mortality
United States epidemiology
Young Adult
Aldosterone physiology
Cardiovascular Diseases mortality
Renin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1787
- Volume :
- 5
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- JACC. Heart failure
- Publication Type :
- Academic Journal
- Accession number :
- 28822744
- Full Text :
- https://doi.org/10.1016/j.jchf.2017.05.012