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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.
- Source :
-
Scientific reports [Sci Rep] 2017 Aug 22; Vol. 7 (1), pp. 9079. Date of Electronic Publication: 2017 Aug 22. - Publication Year :
- 2017
-
Abstract
- Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes. The secretions and plasma contained altered microRNAs whose targets were linked with changes in gene expression in the fetal brain and with human schizophrenia loci. Molecular and morphological changes in vivo and in vitro were prevented by a single dose of MitoQ bound to nanoparticles, which were shown to localise and prevent oxidative stress in the placenta but not in the fetus. We suggest the possibility of developing preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric disease in later life.
- Subjects :
- Animals
Antioxidants metabolism
Biomarkers
Female
Fetus metabolism
Gene Expression
Microscopy, Confocal
Organogenesis
Oxidative Stress
Pregnancy
Rats
Reactive Oxygen Species metabolism
Brain embryology
Brain metabolism
Fetal Development
Hypoxia metabolism
Placenta metabolism
Pregnancy Complications metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28831049
- Full Text :
- https://doi.org/10.1038/s41598-017-06300-1