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Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure.
Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure.
- Source :
-
Industrial health [Ind Health] 2018 Feb 07; Vol. 56 (1), pp. 10-19. Date of Electronic Publication: 2017 Aug 22. - Publication Year :
- 2018
-
Abstract
- Exposure to bioaerosols in indoor animal farms associates with respiratory illnesses, but little is known about the immune modulation to chicken farmers. This study aimed to compare the general immunity of chicken farmers with those of control subjects with non-agricultural jobs. Blood taken from the farmers and controls was subjected to plasma IgE and IgG subclass measurements. Isolated peripheral blood mononuclear cells (PBMC) were stimulated and cytokine production was measured. Indoor total and respirable dust levels and their endotoxin (LPS) and aflatoxin (AF) levels in the farms were measured. In total, 29 chicken farmers on 19 farms and 14 age- and sex-matched office workers participated. Hematological differences were not observed. The farmers tended to have higher serum IgE and IgG subclass levels with significance for IgG1. The cytokines released by PBMC from farmers indicated skewing toward Type-2 helper T-cell responses: interferon (IFN)-γ:interleukin (IL)-4 and IFNγ:IL-13 ratios were significantly lower than for control PBMC. The farms had 707.1 EU/m <superscript>3</superscript> LPS in total dust, and 15.8 EU/m <superscript>3</superscript> LPS in respirable dust. Farmers exhibited immune skewing towards allergic immune responses that correlated with the LPS levels on their farms. Chicken farmers may be at risk of respiratory allergies due to occupational endotoxin exposure.
- Subjects :
- Adult
Aflatoxins analysis
Aged
Air Pollutants, Occupational analysis
Air Pollution, Indoor analysis
Animal Husbandry statistics & numerical data
Animals
Cytokines metabolism
Female
Humans
Immunoglobulin E blood
Immunoglobulin G blood
Leukocytes, Mononuclear metabolism
Male
Middle Aged
Chickens
Dust analysis
Endotoxins analysis
Occupational Exposure analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1880-8026
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Industrial health
- Publication Type :
- Academic Journal
- Accession number :
- 28835578
- Full Text :
- https://doi.org/10.2486/indhealth.2017-0049