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A partially rigid butyrophenone analog with extended conformation.
- Source :
-
Die Pharmazie [Pharmazie] 1986 Dec; Vol. 41 (12), pp. 835-6. - Publication Year :
- 1986
-
Abstract
- The synthesis and in vitro dopamine D2 receptor binding of a conformationally restricted analog of 4-piperidinobutyrophenone is described. 2-(2-Piperidinoethyl)-1-tetralone displaces [3H]spiperone from the rat striatal dopamine receptor with an IC50 of 1.2 X 10(-4)mol/l.
- Subjects :
- Animals
Antipsychotic Agents pharmacology
Binding, Competitive drug effects
Butyrophenones pharmacology
Chemical Phenomena
Chemistry, Physical
Corpus Striatum metabolism
In Vitro Techniques
Magnetic Resonance Spectroscopy
Molecular Conformation
Rats
Receptors, Dopamine metabolism
Spiperone metabolism
Antipsychotic Agents chemical synthesis
Butyrophenones chemical synthesis
Tetralones
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 41
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 2883672