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Development of a head-mounted wireless microstimulator for deep brain stimulation in rats.
- Source :
-
Journal of neuroscience methods [J Neurosci Methods] 2017 Nov 01; Vol. 291, pp. 249-256. Date of Electronic Publication: 2017 Aug 24. - Publication Year :
- 2017
-
Abstract
- Background: Commercial neurostimulators for clinical use are effective in patients; however they are too large and prohibitively expensive for preclinical studies. Thus, there is an urgent need of a small inexpensive and wireless microstimulator which is fully programmable in frequency, pulse width and amplitude for rodent experiments.<br />New Methods: Rats were subjected to a photothrombotic stroke of the right sensorimotor cortex and a microelectrode was implanted in the right mesencephalic locomotor region. The microstimulator was connected with the head plug of the rat. Three different stimulation frequencies were applied and different stimulating amplitudes were chosen. Under these conditions, gait velocity and locomotor behavior of six rats were examined on a beam.<br />Results: The head-mounted microstimulator allowed freedom in all motor activities performed spontaneously by the tested rats. Increasing either the frequency or the stimulating amplitude increased gait velocity and ameliorated locomotor behavior after stroke.<br />Comparison With Existing Methods: Other devices for DBS in rodents must be implanted under the skin or worn in an animal jacket on the back by the tested rat. Some available systems require even a tethering of the tested animal via a cable to an external stimulation system, which limits the freedom of movement.<br />Conclusion: Here, we present a freely programmable microstimulator including DBS-typical stimulating parameters. The lightweight device is connected by a simple plug to the head allowing full freedom of movement and exchange of batteries for long-term experiments. The design of this stimulator is suitable for sophisticated behavior tests requiring balance and skilled walking.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Biomechanical Phenomena
Disease Models, Animal
Equipment Design
Gait physiology
Immunohistochemistry
In Situ Hybridization, Fluorescence
Male
Mesencephalon pathology
Mesencephalon physiopathology
Motor Activity physiology
Rats, Wistar
Sensorimotor Cortex pathology
Sensorimotor Cortex physiopathology
Software
Stroke pathology
Stroke physiopathology
Stroke therapy
Deep Brain Stimulation instrumentation
Implantable Neurostimulators
Microtechnology instrumentation
Wireless Technology instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1872-678X
- Volume :
- 291
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience methods
- Publication Type :
- Academic Journal
- Accession number :
- 28842194
- Full Text :
- https://doi.org/10.1016/j.jneumeth.2017.08.024