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Clinical Impact of Aprepitant in Patients Receiving High-Dose Chemotherapy prior to Autologous Peripheral Blood Stem Cell Transplantation: A Cost-Effectiveness Analysis.
- Source :
-
Oncology [Oncology] 2017; Vol. 93 (5), pp. 302-308. Date of Electronic Publication: 2017 Aug 24. - Publication Year :
- 2017
-
Abstract
- Objective: To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT).<br />Methods: We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and December 2013. Cost-effectiveness was analyzed using direct medical costs.<br />Results: We identified a total of 38 patients (27 with non-Hodgkin lymphoma and 11 with multiple myeloma). Thirteen patients received aprepitant and granisetron (aprepitant group) for CINV prophylaxis, whereas 25 patients received granisetron only (non-aprepitant group). The incidence of severe nausea (≥grade 3) was significantly lower in the aprepitant group than in the non-aprepitant group (p = 0.039). The total mean cost per patient during hospitalization, excluding the cost of HDCT and transplantation, was USD 10,941.8 in the aprepitant group and USD 14,577.2 in the non-aprepitant group (p = 0.041). This cost benefit reflected reductions in the costs of hospitalization, transfusion, and infection treatment.<br />Conclusions: Our data indicated that the addition of aprepitant for CINV prophylaxis during HDCT reduced the incidence of severe nausea and might also provide economic benefit in the overall management of HDCT prior to autologous peripheral blood stem cell transplantation.<br /> (© 2017 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Aprepitant
Cost-Benefit Analysis
Female
Granisetron administration & dosage
Granisetron adverse effects
Humans
Lymphoma, Non-Hodgkin drug therapy
Lymphoma, Non-Hodgkin therapy
Male
Middle Aged
Multiple Myeloma drug therapy
Multiple Myeloma therapy
Nausea chemically induced
Peripheral Blood Stem Cell Transplantation methods
Retrospective Studies
Vomiting chemically induced
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Morpholines administration & dosage
Morpholines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0232
- Volume :
- 93
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28848220
- Full Text :
- https://doi.org/10.1159/000479032