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Isoniazid-induced alteration of CSF neurotransmitter amino acids in Huntington's disease.
- Source :
-
Brain research [Brain Res] 1987 Apr 07; Vol. 408 (1-2), pp. 125-30. - Publication Year :
- 1987
-
Abstract
- During a randomized, double-blind, crossover, placebo-controlled clinical trial of isoniazid (plus pyridoxine) in Huntington's disease (HD), amino acids and related amino compounds were measured in both cerebrospinal fluid (CSF) and plasma utilizing a newly developed high-performance liquid chromatography ion-exchange/fluorometric assay method. Results showed that isoniazid (plus pyridoxine) significantly elevated the mean (+/- S.E.M.) levels of gamma-aminobutyric acid, aspartate, asparagine, homocarnosine, ornithine, histidine, alpha-aminobutyric acid, isoleucine, leucine and alanine in CSF and the levels of beta-alanine in both CSF and plasma. These alterations can be traced to inhibition of decarboxylation and transamination reactions requiring the cofactor pyridoxal phosphate and may be related to the observed equivocal clinical response in the HD patients. The differential influence of isoniazid on plasma and CSF amino acid profiles suggests that alterations of CNS amino acid metabolism may be reflected in CSF, and that isoniazid-induced alterations of amino acid metabolism in the CNS differ from those in the periphery.
- Subjects :
- Adult
Amino Acids blood
Clinical Trials as Topic
Double-Blind Method
Histidine blood
Histidine cerebrospinal fluid
Humans
Huntington Disease blood
Huntington Disease cerebrospinal fluid
Middle Aged
Neurotransmitter Agents blood
Pyridoxine therapeutic use
Random Allocation
gamma-Aminobutyric Acid blood
gamma-Aminobutyric Acid cerebrospinal fluid
Amino Acids cerebrospinal fluid
Huntington Disease drug therapy
Isoniazid therapeutic use
Neurotransmitter Agents cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 408
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 2885064
- Full Text :
- https://doi.org/10.1016/0006-8993(87)90364-7