Back to Search
Start Over
Electrocardiographic alterations induced by AGEPC in Wistar rats in relation to its hypotensive and hematologic effects.
- Source :
-
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology [Comp Biochem Physiol C Comp Pharmacol Toxicol] 1987; Vol. 87 (1), pp. 41-6. - Publication Year :
- 1987
-
Abstract
- AGEPC administration into Wistar rats caused no remarkable thrombocytopenia, slight decrease of the percent count of PMNs in whole blood accompanied by anequal leukocytopenia and a transient increase in hematocrit, due to fluid extraversion. Apart from the dramatic fall in blood pressure caused by AGEPC, relatively sinus bradycardia was recorded at doses over 6 micrograms/kg b.w. S-T segment elevation, mainly evident in II, III and AVF leads, was also recorded within the first minutes after AGEPC administration, at doses over 1 microgram/kg b.w. At lethal doses, various degrees of A-V block resulting in complete A-V block with idioventricular rhythm, or injury pattern resulting in ventricular fibrillation or ventricular flutter, were recorded. At sublethal doses no arrhythic manifestations were recorded, while S-T segment elevation upward inversion became gradually normal.
- Subjects :
- Animals
Arrhythmias, Cardiac chemically induced
Arrhythmias, Cardiac physiopathology
Electrocardiography
Heart drug effects
Hematocrit
Leukocyte Count drug effects
Male
Neutrophils cytology
Neutrophils drug effects
Platelet Activating Factor toxicity
Rats
Rats, Inbred Strains
Blood Pressure drug effects
Heart physiology
Platelet Activating Factor pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0742-8413
- Volume :
- 87
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 2885139
- Full Text :
- https://doi.org/10.1016/0742-8413(87)90177-0