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Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus.
- Source :
-
Neuron [Neuron] 2017 Aug 30; Vol. 95 (5), pp. 1181-1196.e8. - Publication Year :
- 2017
-
Abstract
- Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca <superscript>2+</superscript> channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities. VIDEO ABSTRACT.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Action Potentials physiology
Alcohol Oxidoreductases genetics
Animals
Calcium Channels, T-Type genetics
Calcium Channels, T-Type physiology
Dopamine metabolism
Dystonia diet therapy
Dystonia drug therapy
Dystonia physiopathology
Female
Globus Pallidus cytology
Globus Pallidus metabolism
Levodopa therapeutic use
Male
Metabolism, Inborn Errors diet therapy
Metabolism, Inborn Errors drug therapy
Metabolism, Inborn Errors physiopathology
Mice
Mice, Knockout
Muscle Contraction physiology
Neural Pathways physiology
Neurons physiology
Psychomotor Disorders diet therapy
Psychomotor Disorders drug therapy
Psychomotor Disorders physiopathology
Thalamus cytology
Globus Pallidus physiology
Motor Neurons physiology
Neural Inhibition physiology
Thalamus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 95
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 28858620
- Full Text :
- https://doi.org/10.1016/j.neuron.2017.08.028