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Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes.

Authors :
Li J
Lefebvre Q
Yang H
Zhao Y
Fu H
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Sep 14; Vol. 53 (74), pp. 10299-10302.
Publication Year :
2017

Abstract

α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.

Details

Language :
English
ISSN :
1364-548X
Volume :
53
Issue :
74
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
28869645
Full Text :
https://doi.org/10.1039/c7cc05758j