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Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case - control study.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2017 Sep 04; Vol. 16 (1), pp. 165. Date of Electronic Publication: 2017 Sep 04. - Publication Year :
- 2017
-
Abstract
- Background: Non-alcoholic fatty liver disease (NAFLD) given its association with obesity and diabetes may perhaps exert distinct free fatty acids (FFA) pattern, but the understanding of this phenomenon is limited. To this effect, we evaluated FFA profiles among healthy subjects and NAFLD patients stratified by body weight, to identify FFA valuable for early diagnosis of NAFLD.<br />Methods: Serum FFA profiles of healthy and NAFLD (lean, overweight and obese) subjects was determined using gas chromatography-mass spectrometry (GC-MS) and distinctions in FFA patterns were evaluated using one-way ANOVA while Receiver operating characteristics (ROC) and logistic regression models were used to explore FFA significant for diagnosing NAFLD.<br />Results: NAFLD patients presented significantly higher (P < 0.05) serum FFA profiles compared to healthy controls (HC). While total FFA profiles were insignificantly different between lean (2093.33 ± 558.11 μg/ml) and overweight (2420.81 ± 555.18 μg/ml) NAFLD patients, obese NAFLD (2739.01 ± 810.35 μg/ml) presented most significantly elevated (P < 0.05) total FFA profiles compared with HC. Of the four FFA; myristic acid (14:0), palmitoleic acid (16:1), γ-linolenic acid (γ-18:3) and cis-7,10,13,16,19-docosapentaenoic acid (22:5), selected in ROC analysis given their high Youden's index and AUC, only 14:0; 5.58(1.37, 22.76) and 16:1; 4.36(1.34, 14.13) had statistical significant odd ratios.<br />Conclusion: Our findings suggest 14:0 and 16:1 are promising for early diagnosis of NAFLD.
- Subjects :
- Adult
Body Mass Index
Case-Control Studies
Fatty Acids, Monounsaturated metabolism
Fatty Acids, Unsaturated metabolism
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Middle Aged
Myristic Acid metabolism
Non-alcoholic Fatty Liver Disease metabolism
gamma-Linolenic Acid metabolism
Obesity metabolism
Overweight metabolism
Thinness metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 28870233
- Full Text :
- https://doi.org/10.1186/s12944-017-0551-1