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Haemophilus influenzae type b strains of outer membrane subtypes 1 and 1c cause different types of invasive disease.

Authors :
Takala AK
van Alphen L
Eskola J
Palmgren J
Bol P
Mäkelä PH
Source :
Lancet (London, England) [Lancet] 1987 Sep 19; Vol. 2 (8560), pp. 647-50.
Publication Year :
1987

Abstract

Of 275 consecutive Haemophilus influenzae type b (Hib) strains isolated from children with invasive disease in Finland in 1985-86, 74% were of the common European outer membrane protein (OMP) subtype 1 and 22% were of OMP subtype 1c, which is usually rare. Strains of subtype 1c caused proportionately more meningitis and less epiglottis than did strains of subtype 1c. Furthermore, children with disease due to strains of subtype 1c were younger than those with disease due to strains of subtype 1. The significant difference in association between subtype and the diagnosis of epiglottitis or meningitis remained even when the strong influence of age was accounted for. This finding may suggest a true difference in the virulence between these subtypes not previously demonstrated for Haemophilus influenzae type b.

Details

Language :
English
ISSN :
0140-6736
Volume :
2
Issue :
8560
Database :
MEDLINE
Journal :
Lancet (London, England)
Publication Type :
Academic Journal
Accession number :
2887940
Full Text :
https://doi.org/10.1016/s0140-6736(87)92440-8