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Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011.
- Source :
-
Cancer medicine [Cancer Med] 2017 Oct; Vol. 6 (10), pp. 2203-2212. Date of Electronic Publication: 2017 Sep 06. - Publication Year :
- 2017
-
Abstract
- Women diagnosed with cutaneous melanoma have a survival advantage compared to men, which has been hypothesized to be due to difference in behavior and/or biology (sex hormones). It remains controversial whether this advantage is dependent on age or stage of disease. We sought to compare melanoma-specific survival between females in pre, peri, and postmenopausal age groups to males in the same age group, adjusting for stage of disease. This is a retrospective population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Patients diagnosed from 1 January 1992 through 31 January 2011 with primary invasive cutaneous melanoma were included in our cohort. Melanoma-specific survival was the main outcome studied. Of the 106,511 subjects that were included, 45% were female. Females in all age groups (18-45, 46-54, and ≥55) with localized and regional disease, were less likely to die from melanoma compared to males in the same age group. Among patients with localized and regional disease, the relative risk of death due to melanoma increased with advancing age at diagnosis; this increase was more pronounced among females than males. In contrast, we observed no female survival advantage among patients with distant disease and no effect of age on relative risk of death from melanoma. Females with localized and regional melanoma have a decreased risk of death compared to males within all age groups. Our data show no differences in survival between men and women with metastatic melanoma, indicating that the influence of sex on survival is limited to early stage disease but not confined to pre or perimenopausal age groups.<br /> (© 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Female
History, 20th Century
History, 21st Century
Humans
Male
Melanoma epidemiology
Melanoma history
Melanoma pathology
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Population Surveillance
Proportional Hazards Models
Registries
SEER Program
Sex Factors
Skin Neoplasms epidemiology
Skin Neoplasms history
Skin Neoplasms pathology
United States epidemiology
Young Adult
Melanoma, Cutaneous Malignant
Melanoma mortality
Skin Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2045-7634
- Volume :
- 6
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28879661
- Full Text :
- https://doi.org/10.1002/cam4.1152