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Pharmacokinetic/Toxicodynamic Analysis of Colistin-Associated Acute Kidney Injury in Critically Ill Patients.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Oct 24; Vol. 61 (11). Date of Electronic Publication: 2017 Oct 24 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.<br /> (Copyright © 2017 American Society for Microbiology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents blood
Colistin adverse effects
Colistin blood
Creatinine blood
Critical Illness
Female
Humans
Male
Middle Aged
Acute Kidney Injury chemically induced
Anti-Bacterial Agents pharmacokinetics
Colistin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 61
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28893780
- Full Text :
- https://doi.org/10.1128/AAC.01367-17