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Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2018 Feb; Vol. 138 (2), pp. 355-364. Date of Electronic Publication: 2017 Sep 18. - Publication Year :
- 2018
-
Abstract
- Vitiligo is a chronic autoimmune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (T <subscript>RM</subscript> ). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 T <subscript>RM</subscript> expressing both CD69 and CD103 compared with psoriasis and control unaffected skin. CD8 T <subscript>RM</subscript> expressing CD103 are mainly localized in the epidermis. Expression of CXCR3 is observed on most CD8 T <subscript>RM</subscript> in vitiligo, including the population of melanocyte-specific CD8 T cells. CD8 T <subscript>RM</subscript> displayed increased production of IFN-γ and tumor necrosis factor-α with moderate cytotoxic activity. Our study highlights the presence of functional CD8 T <subscript>RM</subscript> in both stable and active vitiligo, reinforcing the concept of vitiligo as an immune memory skin disease. The CD8 T <subscript>RM</subscript> that remain in stable disease could play a role during disease flares, emphasizing the interest in targeting this cell subset in vitiligo.<br /> (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Biopsy
CD8-Positive T-Lymphocytes metabolism
Female
Humans
Male
Middle Aged
Receptors, CXCR3 immunology
Skin cytology
Skin pathology
Vitiligo blood
Vitiligo pathology
CD8-Positive T-Lymphocytes immunology
Immunologic Memory immunology
Receptors, CXCR3 metabolism
Skin immunology
Vitiligo immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 138
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 28927891
- Full Text :
- https://doi.org/10.1016/j.jid.2017.08.038