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Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.
- Source :
-
Scientific reports [Sci Rep] 2017 Sep 22; Vol. 7 (1), pp. 12211. Date of Electronic Publication: 2017 Sep 22. - Publication Year :
- 2017
-
Abstract
- The proteinase 3 (PR3)-positive anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) granulomatosis with polyangiitis (GPA) has been associated with chronic nasal S. aureus carriage, which is a risk factor for disease relapse. The present study was aimed at comparing the genetic make-up of S. aureus isolates from PR3-ANCA-positive GPA patients with that of isolates from patients suffering from myeloperoxidase (MPO)-ANCA-positive AAV, and isolates from healthy controls. Based on a DNA microarray-based approach, we show that not only PR3-ANCA-positive GPA patients, but also MPO-ANCA-positive AAV patients mainly carried S. aureus types that are prevalent in the general population. Nonetheless, our data suggests that MPO-ANCA-associated S. aureus isolates may be distinct from healthy control- and PR3-ANCA-associated isolates. Furthermore, several genetic loci of S. aureus are associated with either PR3-ANCA- or MPO-ANCA-positive AAV, indicating a possible role for pore-forming toxins, such as leukocidins, in PR3-ANCA-positive GPA. Contrary to previous studies, no association between AAV and superantigens was detected. Our findings also show that a lowered humoral immune response to S. aureus is common for PR3-ANCA- and MPO-ANCA-positive AAV. Altogether, our observations imply that the presence or absence of particular virulence genes of S. aureus isolates from AAV patients contributes to disease progression and/or relapse.
- Subjects :
- Adult
Aged
Antibodies, Antineutrophil Cytoplasmic immunology
Carrier State blood
Carrier State immunology
Carrier State microbiology
Female
Granulomatosis with Polyangiitis blood
Granulomatosis with Polyangiitis immunology
Host-Pathogen Interactions genetics
Host-Pathogen Interactions immunology
Humans
Male
Middle Aged
Myeloblastin immunology
Peroxidase immunology
Recurrence
Retrospective Studies
Staphylococcal Infections blood
Staphylococcal Infections immunology
Staphylococcus aureus immunology
Staphylococcus aureus isolation & purification
Young Adult
Antibodies, Antineutrophil Cytoplasmic blood
Genetic Loci immunology
Granulomatosis with Polyangiitis microbiology
Staphylococcal Infections microbiology
Staphylococcus aureus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28939882
- Full Text :
- https://doi.org/10.1038/s41598-017-12450-z