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Spastic paraparesis and HTLV-I infection in Peru.
- Source :
-
Annals of neurology [Ann Neurol] 1988; Vol. 23 Suppl, pp. S151-5. - Publication Year :
- 1988
-
Abstract
- Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T-helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.
- Subjects :
- Adult
Aged
Antibodies, Viral analysis
Antibodies, Viral cerebrospinal fluid
Blood Cells pathology
Cell Division
Deltaretrovirus Antibodies
Female
Humans
Leukocytes, Mononuclear pathology
Male
Middle Aged
Muscle Spasticity cerebrospinal fluid
Muscle Spasticity etiology
Muscle Spasticity immunology
Muscle Spasticity pathology
Myelitis etiology
Paraplegia cerebrospinal fluid
Paraplegia immunology
Paraplegia pathology
Peru
T-Lymphocytes classification
Deltaretrovirus Infections cerebrospinal fluid
Deltaretrovirus Infections immunology
Deltaretrovirus Infections pathology
Paraplegia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0364-5134
- Volume :
- 23 Suppl
- Database :
- MEDLINE
- Journal :
- Annals of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 2894807
- Full Text :
- https://doi.org/10.1002/ana.410230734