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Hepatitis C Virus-Associated Extrahepatic Manifestations in Lung and Heart and Antiviral Therapy-Related Cardiopulmonary Toxicity.

Authors :
Ilyas SZ
Tabassum R
Hamed H
Rehman SU
Qadri I
Source :
Viral immunology [Viral Immunol] 2017 Nov; Vol. 30 (9), pp. 633-641. Date of Electronic Publication: 2017 Sep 27.
Publication Year :
2017

Abstract

Besides liver cirrhosis and hepatocellular carcinoma, chronic hepatitis C virus (HCV) infection is associated with many extrahepatic manifestations (EHMs). HCV exhibits lymphotropism that is responsible for various EHM. An important characteristic of HCV is escape from the immune system, which enables it to produce chronic infections and autoimmune disorders along with accumulation of circulating immune complexes. These EHMs have large spectrum, because they affect many organs such as heart, lungs, kidney, brain, thyroid, and skin. HCV-related cardiac and pulmonary manifestations include myocarditis, cardiomyopathies, cardiovascular diseases (i.e., Stroke, ischemic heart disease), chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, and interstitial lung diseases. This review discusses etiology and pathogenesis of HCV-associated cardiac and pulmonary manifestations and how different genes, immune system, indirectly linked factors (mixed cryoglobulinemia), liver cirrhosis, and antiviral treatment are involved in HCV-related heart and lung diseases, however, their exact mechanism is not clear.

Details

Language :
English
ISSN :
1557-8976
Volume :
30
Issue :
9
Database :
MEDLINE
Journal :
Viral immunology
Publication Type :
Academic Journal
Accession number :
28953449
Full Text :
https://doi.org/10.1089/vim.2017.0009