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Hepatitis C Virus-Associated Extrahepatic Manifestations in Lung and Heart and Antiviral Therapy-Related Cardiopulmonary Toxicity.
- Source :
-
Viral immunology [Viral Immunol] 2017 Nov; Vol. 30 (9), pp. 633-641. Date of Electronic Publication: 2017 Sep 27. - Publication Year :
- 2017
-
Abstract
- Besides liver cirrhosis and hepatocellular carcinoma, chronic hepatitis C virus (HCV) infection is associated with many extrahepatic manifestations (EHMs). HCV exhibits lymphotropism that is responsible for various EHM. An important characteristic of HCV is escape from the immune system, which enables it to produce chronic infections and autoimmune disorders along with accumulation of circulating immune complexes. These EHMs have large spectrum, because they affect many organs such as heart, lungs, kidney, brain, thyroid, and skin. HCV-related cardiac and pulmonary manifestations include myocarditis, cardiomyopathies, cardiovascular diseases (i.e., Stroke, ischemic heart disease), chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, and interstitial lung diseases. This review discusses etiology and pathogenesis of HCV-associated cardiac and pulmonary manifestations and how different genes, immune system, indirectly linked factors (mixed cryoglobulinemia), liver cirrhosis, and antiviral treatment are involved in HCV-related heart and lung diseases, however, their exact mechanism is not clear.
- Subjects :
- Cryoglobulinemia pathology
Heart virology
Hepatitis C, Chronic drug therapy
Hepatitis C, Chronic immunology
Hepatitis C, Chronic virology
Humans
Idiopathic Pulmonary Fibrosis pathology
Immune Evasion immunology
Lung pathology
Lung virology
Myocarditis pathology
Myocardium pathology
Pulmonary Disease, Chronic Obstructive pathology
Cryoglobulinemia virology
Hepacivirus immunology
Hepatitis C, Chronic pathology
Idiopathic Pulmonary Fibrosis virology
Myocarditis virology
Pulmonary Disease, Chronic Obstructive virology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8976
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Viral immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28953449
- Full Text :
- https://doi.org/10.1089/vim.2017.0009