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Association between body shape index and small dense LDL particles in a cohort of mediterranean women: findings from Progetto ATENA.
- Source :
-
Journal of clinical biochemistry and nutrition [J Clin Biochem Nutr] 2017 Sep; Vol. 61 (2), pp. 130-134. Date of Electronic Publication: 2017 Aug 11. - Publication Year :
- 2017
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Abstract
- Small dense LDL particles (sd-LDL) and body shape index (ABSI), were evaluated in 228 women, living in Naples, Italy (Progetto ATENA). Serum cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, HOMA, Apo B, hs-CPR and sd-LDL were measured. LDL particle separation was performed by Lipoprint System: seven LDL subfractions were obtained and LDL score (% of sd-LDL particles) calculated. ABSI was calculated according to Krakauer's formula: ABSI (m <superscript>11/6</superscript>  kg <superscript>-2/3</superscript> ). The association between sd-LDL and ABSI was evaluated taking into account different adjustment models. Women with elevated levels of ABSI show the following OR of having high LDL score: 2.39, p  = 0.002; unadjusted; 2.47, p  = 0.002; adjusted for age; 2.13, p  = 0.011; adjusted for age and Apo B; 1.93, p  = 0.026; adjusted for age and Apo B and triglycerides. ABSI was associated with elevated LDL score independently of age, Systolic pressure, Apo B and triglycerides. Median of LDL diameter decreased among ABSI quartiles: quartile I: 271.5 nm, quartile II: 270.7 nm, quartile III 270.5 nm, quartile IV 269.4 nm; Kruskall Wallis Test: p  = 0.016. These results are in line with the hypothesis that ABSI could be a marker of visceral abdominal associated to adverse metabolic changes including presence of elevated sd-LDL, a risk factor for premature cardiovascular disease.<br />Competing Interests: No potential conflicts of interest were disclosed.
Details
- Language :
- English
- ISSN :
- 0912-0009
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical biochemistry and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 28955130
- Full Text :
- https://doi.org/10.3164/jcbn.17-13