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Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2018 Feb 01; Vol. 197 (3), pp. 364-372. - Publication Year :
- 2018
-
Abstract
- Rationale: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions.<br />Objectives: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life.<br />Methods: A cohort of 2,404 neonates was followed to 5 years of age in a rural district in coastal Ecuador. Data on wheeze were collected by questionnaire and atopy was measured by allergen skin prick test reactivity to 10 allergens at 5 years. Stool samples from mothers and children were examined for geohelminths by microscopy.<br />Measurements and Main Results: A total of 2,090 (86.9%) children were evaluated at 5 years. Geohelminths were observed in 45.5% of mothers and in 34.1% of children by 3 years. Wheeze and asthma were reported for 12.6% and 5.7% of children, respectively, whereas 14.0% had skin test reactivity at 5 years. Maternal geohelminths were associated with an increased risk of wheeze (adjusted odds ratio, 1.41; 95% confidence interval, 1.06-1.88), whereas childhood geohelminths over the first 3 years of life were associated with reduced risk of wheeze (adjusted odds ratio, 0.70; 95% confidence interval, 0.52-0.96) and asthma (adjusted odds ratio, 0.60; 95% confidence interval, 0.38-0.94) but not skin prick test reactivity. The effects on wheeze/asthma were greatest with later age of first infection, were observed only in skin test-negative children, but were not associated with parasite burden or specific geohelminths.<br />Conclusions: Although maternal exposures to geohelminths may increase childhood wheeze, childhood geohelminths during the first 3 years may provide protection through a nonallergic mechanism. Registered as an observational study (ISRCTN41239086).
- Subjects :
- Adult
Age Factors
Allergens immunology
Animals
Asthma prevention & control
Child, Preschool
Cohort Studies
Developing Countries
Ecuador
Eczema immunology
Eczema prevention & control
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Respiratory Sounds immunology
Risk Assessment
Time Factors
Asthma immunology
Helminthiasis immunology
Helminths immunology
Maternal Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1535-4970
- Volume :
- 197
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28957644
- Full Text :
- https://doi.org/10.1164/rccm.201706-1222OC