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Silver-Mediated Direct C-H Cyanation of Terminal Alkynes with N-Isocyanoiminotriphenylphosphorane.
- Source :
-
Organic letters [Org Lett] 2017 Oct 20; Vol. 19 (20), pp. 5613-5616. Date of Electronic Publication: 2017 Sep 29. - Publication Year :
- 2017
-
Abstract
- A direct cyanation of terminal alkynes for the synthesis of propionitrile derivatives, with the aid of silver salt using water additive, has been achieved. The cyano source used is N-isocyanoiminotriphenylphosphorane, which is nontoxic, safe, and easy to handle. This protocol is characterized by its operational simplicity, high efficiency with excellent yields, broad substrate scope, and greater functional group tolerance.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28961010
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b02743