The association of air pollution with height: Evidence from Hong Kong's "Children of 1997" birth cohort.

Objectives: Within populations, height is positively associated with economic success and in economically developed populations inversely associated with health. Recent studies also suggest air pollution may result in higher bone turnover markers among children, which may affect growth. However, few studies have investigated the effect of air pollution on height or growth rate. We therefore assessed the associations of several air pollutants with height at different ages.
Methods: We simultaneously assessed associations of particulate matter with a diameter of 10 micrometers or less (PM ₁₀ ), sulfur dioxide (SO ₂ ), nitric oxide (NO), and nitrogen dioxide (NO ₂ ) in utero, in infancy, and in childhood with height at different ages (∼9, ∼11, ∼13, and ∼15 years), in a population-representative birth cohort "Children of 1997" (n = 8327) from the developed non-Western setting of Hong Kong with relatively high air pollution and short children, using partial least square regression.
Results: After considering multiple comparison, higher SO ₂ in childhood was associated with shorter height at ∼13 years (-0.20 cm, 99% CI -0.32 to -0.06). This difference was not evident at ∼15 years.
Conclusions: These observations suggest that air pollution may affect the trajectory of growth and development rather than final height, with corresponding implications for health in later life.
(© 2017 Wiley Periodicals, Inc.)