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Determination and Safety Assessment of Residual Spirotetramat and Its Metabolites in Amaranth ( Amaranthus tricolor ) and Soil by Liquid Chromatography Triple-Quadrupole Tandem Mass Spectrometry.
- Source :
-
Journal of AOAC International [J AOAC Int] 2018 May 01; Vol. 101 (3), pp. 848-857. Date of Electronic Publication: 2017 Oct 05. - Publication Year :
- 2018
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Abstract
- With the purpose of guaranteeing the safe use of spirotetramat and preventing its potential health threats to consumers, a QuEChERS extraction method coupled with LC triple-quadrupole tandem MS was applied in this study to determine residual spirotetramat metabolites in different tissues of amaranth (Amaranthus tricolor) and in soil. The results indicate that the spirotetramat degraded into different types of metabolites that were located in different tissues of amaranth and in soil. B-keto, B-glu, and B-enol were the three most representative degradation products in the leaf of amaranth, and B-glu and B-enol were the two major degradation products found in the stem of amaranth; however, only B-enol was detected in the root of amaranth. B-keto and B-mono were the two products detected in the soil in which the amaranth grew. The cytotoxicity results demonstrate that spirotetramat and its metabolite B-enol inhibited cellular growth, and the toxicity of spirotetramat and its metabolite B-enol exceeded than that of the metabolites B-keto, B-mono, and B-glu. This investigation is of great significance to the safe use of spirotetramat in agriculture.
- Subjects :
- Amaranthus chemistry
Amaranthus metabolism
Animals
Aza Compounds isolation & purification
Aza Compounds metabolism
Aza Compounds toxicity
Cell Line
Cell Proliferation drug effects
Insecticides isolation & purification
Insecticides metabolism
Insecticides toxicity
Limit of Detection
Plant Leaves chemistry
Plant Leaves metabolism
Plant Roots chemistry
Plant Roots metabolism
Plant Stems chemistry
Plant Stems metabolism
Soil chemistry
Spiro Compounds isolation & purification
Spiro Compounds metabolism
Spiro Compounds toxicity
Spodoptera drug effects
Aza Compounds analysis
Chromatography, Liquid methods
Insecticides analysis
Spiro Compounds analysis
Tandem Mass Spectrometry methods
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7922
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of AOAC International
- Publication Type :
- Academic Journal
- Accession number :
- 28982415
- Full Text :
- https://doi.org/10.5740/jaoacint.17-0216