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Biomarker Potential of Extracellular miRNAs in Duchenne Muscular Dystrophy.

Authors :
Coenen-Stass AML
Wood MJA
Roberts TC
Source :
Trends in molecular medicine [Trends Mol Med] 2017 Nov; Vol. 23 (11), pp. 989-1001. Date of Electronic Publication: 2017 Oct 05.
Publication Year :
2017

Abstract

miRNAs are small, noncoding RNAs that not only regulate gene expression within cells, but might also constitute promising extracellular biomarkers for a variety of pathologies, including the progressive muscle-wasting disorder Duchenne Muscular Dystrophy (DMD). A set of muscle-enriched miRNAs, the myomiRs (miR-1, miR-133, and miR-206) are highly elevated in the serum of patients with DMD and in dystrophin-deficient animal models. Furthermore, circulating myomiRs might be used as pharmacodynamic biomarkers, given that their levels can be restored towards wild-type levels following exon skipping therapy in dystrophic mice. The relationship between muscle pathology and extracellular myomiR release is complex, and incompletely understood. Here, we discuss current progress leading towards the clinical utility of extracellular miRNAs as putative DMD biomarkers, and their possible contribution to muscle physiology.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1471-499X
Volume :
23
Issue :
11
Database :
MEDLINE
Journal :
Trends in molecular medicine
Publication Type :
Academic Journal
Accession number :
28988850
Full Text :
https://doi.org/10.1016/j.molmed.2017.09.002