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Autoimmunity associated with chemically induced thymic dysplasia.
- Source :
-
International immunology [Int Immunol] 2017 Aug 01; Vol. 29 (8), pp. 385-390. - Publication Year :
- 2017
-
Abstract
- Autoimmune and inflammatory conditions are frequent complications in patients with reduced numbers of T cells. Here, we describe a mouse model of thymic stromal dysplasia resulting in peripheral T-cell lymphopenia. In Foxn1:CFP-NTR transgenic mice, the bacterial nitroreductase enzyme is expressed in thymic epithelial cells and converts the prodrug CB1954 into a cytotoxic agent. This strategy enables titratable and durable destruction of thymopoietic tissue in early embryogenesis. Our results indicate that the resulting low levels of thymic capacity for T-cell production create a predisposition for the development of a complex autoimmune syndrome, chiefly characterized by inflammatory bowel disease and lymphocytic organ infiltrations. We conclude that the Foxn1:CFP-NTR transgenic mouse strain represents a suitable animal model to optimize established clinical protocols, such as thymus transplantation, to correct various forms of thymic dysplasia and to explore novel treatment options.<br /> (© The Author 2017. Published by Oxford University Press on behalf of The Japanese Society for Immunology.)
- Subjects :
- Anaplasia
Animals
Antineoplastic Agents pharmacology
Apoptosis
Autoimmunity
Aziridines pharmacology
Disease Models, Animal
Forkhead Transcription Factors genetics
Humans
Lymphopenia
Mice
Mice, Inbred C57BL
Mice, Transgenic
Inflammatory Bowel Diseases immunology
T-Lymphocytes physiology
Thymus Gland pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2377
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28992076
- Full Text :
- https://doi.org/10.1093/intimm/dxx048