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Prenatal Exposure to LPS Alters The Intrarenal RAS in Offspring, Which Is Ameliorated by Adipose Tissue-Derived Mesenchymal Stem Cells.
- Source :
-
American journal of hypertension [Am J Hypertens] 2017 Nov 06; Vol. 30 (12), pp. 1211-1219. - Publication Year :
- 2017
-
Abstract
- Background: Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cells (ADSCs) can ameliorate the effects of prenatal LPS exposure in rat offspring.<br />Methods: Sixty-four pregnant rats were randomly divided into 4 groups (n = 16 in each), namely, a control group and an LPS group, which were intraperitoneally injected with vehicle and 0.79 mg/kg LPS, respectively, on the 8th, 10th, and 12th days of gestation; an ADSCs group, which was intravenously injected with 1.8 × 107 ADSCs on the 8th, 10th, and 12th days of gestation; and an LPS + ADSCs group, which received a combination of the treatments administered to the LPS and ADSCs groups.<br />Results: Prenatal LPS exposure increased blood pressure, Ang II expression, Ang II-positive, monocyte and lymphocyte, apoptotic cells in the kidney, and induced renal histological changes in offspring; however, the LPS and control groups did not differ significantly with respect to plasma renin activity levels, Ang II levels, or renal function. ADSCs treatment attenuated the blood pressure and also ameliorated the other effects of LPS-treated adult offspring.<br />Conclusions: Prenatal exposure to LPS activates the intrarenal RAS but not the circulating RAS and thus induces increases in blood pressure in adult offspring; however, ADSCs treatment attenuates the blood pressure increases resulting from LPS exposure and also ameliorates the other phenotypic changes induced by LPS treatment by inhibiting intrarenal RAS activation.<br /> (© American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: journals.permissions@oup.com)
- Subjects :
- Angiotensin II biosynthesis
Angiotensin II blood
Animals
Apoptosis drug effects
Blood Pressure
Female
Kidney pathology
Kidney Function Tests
Mesenchymal Stem Cells
Myocardium pathology
Pregnancy
Prenatal Exposure Delayed Effects physiopathology
Rats
Rats, Sprague-Dawley
Adipose Tissue chemistry
Kidney drug effects
Lipopolysaccharides toxicity
Mesenchymal Stem Cell Transplantation
Prenatal Exposure Delayed Effects chemically induced
Renin-Angiotensin System drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7225
- Volume :
- 30
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 28992100
- Full Text :
- https://doi.org/10.1093/ajh/hpx117