Back to Search
Start Over
Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 1988 Sep; Vol. 82 (3), pp. 797-802. - Publication Year :
- 1988
-
Abstract
- This study examines the potential influence of genetic variation on the metabolism of LDL. Restriction fragment length polymorphisms (RFLP) of the gene coding for apo B were identified using the endonucleases Xba I, Eco RI, and Msp I in a group of 19 subjects with moderate hyperlipidemia. There was a significant association between the Xba I polymorphism and the total fractional clearance rate (FCR) of LDL. The individuals with the X1X1 genotype had, on average, a 22% higher FCR (P less than 0.025) than those with the genotype X2X2 (X2 allele = presence of Xba I cutting site). This difference was attributable to increased clearance by the receptor-mediated pathway of LDL catabolism. In this group of subjects, there was no association of LDL kinetic parameters and RFLPs of the LDL receptor gene or the AI- CIII- AIV gene cluster. The data suggest that variation in apo B itself, presumably acting through variable binding to the LDL receptor, makes a significant contribution to the rate of catabolism of LDL.
Details
- Language :
- English
- ISSN :
- 0021-9738
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 2901432
- Full Text :
- https://doi.org/10.1172/JCI113681