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LPS priming in early life decreases antigen uptake of dendritic cells via NO production.
- Source :
-
Immunobiology [Immunobiology] 2018 Jan; Vol. 223 (1), pp. 25-31. Date of Electronic Publication: 2017 Oct 09. - Publication Year :
- 2018
-
Abstract
- Immunological mechanisms of hygiene hypothesis are expected to develop a novel strategy for allergy prevention. Although a large number of studies has investigated the relation between allergies and infection, little is known about the influence of the exposure to infections on antigen uptake by dendritic cells (DCs). In this study, we examined the effect of lipopolysaccharide (LPS) priming in early life on the antigen uptake ability of DCs by using an original mouse model. LPS priming in juvenile mice decreased the migration of antigen-capturing CD11c <superscript>+</superscript> cells in the lymph nodes, but not in aged mice. Besides, the bone marrow-derived DCs (BMDCs) from juvenile LPS-primed mice had the poor antigen uptake ability, and constitutively produced NO through the inducible nitric oxide synthase (iNOS). Interestingly, the LPS priming-induced poor antigen uptake of BMDCs was mimicked by the NO donor, and recovered by the iNOS inhibitor. Additionally, LPS priming in juvenile mice prevented the allergic reactions, but not in aged mice. Our results suggested that an exposure to infections in early life prevents allergy through the alteration of the BM cells fate that is to induce the differentiation of BM cells into inhibitory DCs such as NO-producing DCs.<br /> (Copyright © 2017 Elsevier GmbH. All rights reserved.)
- Subjects :
- Aging immunology
Animals
Antigen Presentation
Antigens metabolism
CD11c Antigen metabolism
Cell Movement
Disease Models, Animal
Endocytosis
Environmental Exposure adverse effects
Humans
Hygiene Hypothesis
Immunization
Male
Mice
Mice, Inbred BALB C
Dendritic Cells immunology
Hypersensitivity immunology
Infections immunology
Lipopolysaccharides immunology
Nitric Oxide metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3279
- Volume :
- 223
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 29030010
- Full Text :
- https://doi.org/10.1016/j.imbio.2017.10.018