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Advances in microRNA analysis.
- Source :
-
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2018 Jan; Vol. 410 (3), pp. 695-713. Date of Electronic Publication: 2017 Oct 14. - Publication Year :
- 2018
-
Abstract
- MicroRNAs (miRNAs) are single-stranded noncoding RNA molecules that act as key regulators of mRNA expression and are emerging biomarkers for disease. Their small size (18-25 nt) presents challenges to molecular recognition, labeling, and signal generation. Recent research activity in this field has aimed at the development of methods for miRNA quantification that combine high detectability, broad dynamic range, practicality, multiplexity, and low cost for prospective applications in diagnostic laboratories. This review article covers the most recent advances in microRNA analysis.
- Subjects :
- Animals
Biosensing Techniques instrumentation
Biosensing Techniques methods
Chemistry Techniques, Analytical instrumentation
Electrochemical Techniques instrumentation
Electrochemical Techniques methods
Equipment Design
Fluorometry instrumentation
Fluorometry methods
Humans
Luminescent Measurements instrumentation
Luminescent Measurements methods
Mass Spectrometry instrumentation
Mass Spectrometry methods
MicroRNAs genetics
Nucleic Acid Amplification Techniques instrumentation
Nucleic Acid Amplification Techniques methods
Nucleic Acid Hybridization methods
Photometry instrumentation
Photometry methods
Quartz Crystal Microbalance Techniques instrumentation
Quartz Crystal Microbalance Techniques methods
Spectrum Analysis, Raman instrumentation
Spectrum Analysis, Raman methods
Chemistry Techniques, Analytical methods
MicroRNAs analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1618-2650
- Volume :
- 410
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Analytical and bioanalytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29032457
- Full Text :
- https://doi.org/10.1007/s00216-017-0632-z