Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.

Authors :: Yamane S
Inagaki N
Source :: Journal of diabetes investigation [J Diabetes Investig] 2018 Mar; Vol. 9 (2), pp. 262-264. Date of Electronic Publication: 2017 Dec 01.
Publication Year :: 2018
Abstract: Gut microbiota dysbiosis reduces expression of GLP-1 receptor (GLP-1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP-1-induced nitric oxide (NO) production through a pattern recognition receptor (PRR)-dependent mechanism, hence preventing activation of the gut-brain-periphery axis for control of insulin secretion and gastric emptying.<br /> (© 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)