Effects of sodium β-sitosteryl sulfate on the phase behavior of dipalmitoylphosphatidylcholine.

Authors :: Kafle A
Misono T
Bhadani A
Sakai K
Kaise C
Kaneko T
Sakai H
Source :: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2018 Jan 01; Vol. 161, pp. 59-66. Date of Electronic Publication: 2017 Oct 06.
Publication Year :: 2018
Abstract: We have studied the phase behavior of dipalmitoylphosphatidylcholine (DPPC) containing sodium β-sitosteryl sulfate (PSO <subscript>4</subscript> ). PSO <subscript>4</subscript> was found to lower the phase transition temperature of DPPC to a higher degree than cholesterol or β-sitosterol. It also gave rise to the formation of a modulated (ripple) phase (P <subscript>β</subscript> ) at low to moderate concentrations. At concentrations greater than 25 mol%, it completely changed the membrane into a fluid phase. This shows that PSO <subscript>4</subscript> is capable of disordering the hydrocarbon chains of PC efficiently. The characteristics of PSO <subscript>4</subscript> for fluidizing the membrane can be useful for the pharmaceutical and cosmetics industries.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: Cholesterol chemistry
Freeze Fracturing methods
Lipid Bilayers chemistry
Membrane Fluidity
Microscopy, Electron, Transmission
Scattering, Small Angle
X-Ray Diffraction
1,2-Dipalmitoylphosphatidylcholine chemistry
Phase Transition
Sitosterols chemistry
Transition Temperature

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