Back to Search
Start Over
[Risk factors and survival analysis for synchronous esophageal carcinoma in patients with hypopharyngeal carcinoma].
- Source :
-
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery [Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2017 Oct 07; Vol. 52 (10), pp. 749-754. - Publication Year :
- 2017
-
Abstract
- Objective: To investigate the risk factors and survival status of hypopharyngeal carcinoma with synchronous second primary carcinoma of the esophagus. Methods: One hundred and sixty patients with newly diagnosed hypopharyngeal carcinoma from January 2009 to December 2012 were retrospectively reviewed. The clinical data, tumor-related information and follow-up results were collected and analyzed. Results: Forty-three synchronous esophageal carcinomas (27%) were detected in 160 patients with hypopharyngeal carcinoma, and most patients (72%) were at an early stage. On univariate analysis, the median age of less than 55 years old (χ(2)=4.525, P =0.033), excessive alcohol consumption (χ(2)=6.942, P =0.008) and invasion site more than 3 anatomical regions (χ(2)=21.503, P =0.000) had a significant correlation with the occurrence of synchronous esophageal carcinomas. Multivariate analysis showed that excessive alcohol consumption ( OR =4.787, P =0.029) and invasion site more than 3 anatomical regions ( OR =14.391, P =0.000) were independent risk factors. The median survival time was 26 months in 43 patients with synchronous esophageal carcinomas, which was significantly lower than that (58 months) in patients without secondary primary esophageal carcinomas (χ(2)=11.981, P =0.001). Conclusions: There is a high incidence of synchronous esophageal carcinoma in hypopharyngeal carcinoma patients, affecting the prognosis of hypopharyngeal carcinoma. Surveillance for esophageal carcinomas in patients with hypopharyngeal carcinoma, especially in excessive alcohol drinkers, is warranted.
- Subjects :
- Esophageal Neoplasms diagnosis
Esophageal Neoplasms etiology
Humans
Hypopharyngeal Neoplasms etiology
Middle Aged
Neoplasms, Multiple Primary etiology
Neoplasms, Second Primary diagnosis
Neoplasms, Second Primary etiology
Retrospective Studies
Risk Factors
Survival Analysis
Alcohol Drinking adverse effects
Esophageal Neoplasms mortality
Hypopharyngeal Neoplasms mortality
Neoplasms, Multiple Primary mortality
Neoplasms, Second Primary mortality
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1673-0860
- Volume :
- 52
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29050092
- Full Text :
- https://doi.org/10.3760/cma.j.issn.1673-0860.2017.10.007