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Ivermectin reduces motor coordination, serum testosterone, and central neurotransmitter levels but does not affect sexual motivation in male rats.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2017 Dec; Vol. 74, pp. 195-203. Date of Electronic Publication: 2017 Oct 18. - Publication Year :
- 2017
-
Abstract
- Ivermectin (IVM) is a macrocyclic lactone used for the treatment of parasitic infections and widely used in veterinary medicine as endectocide. In mammals, evidence indicates that IVM interacts with γ-aminobutyric acid (GABA)-mediated chloride channels. GABAergic system is involved in the manifestation of sexual behavior. We previously found that IVM at therapeutic doses did not alter sexual behavior in male rats, but at a higher dose, the appetitive phase of sexual behavior was impaired. Thus, we investigated whether the reduction of sexual behavior that was previously observed was a consequence of motor or motivational deficits that are induced by IVM. Data showed significant decrease in striatal dopaminergic system activity and lower testosterone levels but no effects on sexual motivation or penile erection. These findings suggest IVM may activate the GABAergic system and reduce testosterone levels, resulting in a reduction of motor coordination as consequence of the inhibition of striatal dopamine release.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Corpus Striatum drug effects
Corpus Striatum metabolism
Dopamine metabolism
Female
Hypothalamus drug effects
Hypothalamus metabolism
Male
Penile Erection drug effects
Psychomotor Performance drug effects
Rats, Wistar
Serotonin metabolism
Sexual Behavior, Animal drug effects
Testosterone blood
gamma-Aminobutyric Acid metabolism
Antiparasitic Agents toxicity
Ivermectin toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1708
- Volume :
- 74
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 29055807
- Full Text :
- https://doi.org/10.1016/j.reprotox.2017.10.002