Back to Search
Start Over
Enhancement of dopamine metabolism in rat brain frontal cortex: a common effect of chronically administered antipsychotic drugs.
Enhancement of dopamine metabolism in rat brain frontal cortex: a common effect of chronically administered antipsychotic drugs.
- Source :
-
Brain research [Brain Res] 1988 Dec 20; Vol. 475 (2), pp. 380-4. - Publication Year :
- 1988
-
Abstract
- Administration of 4 antipsychotic drugs, haloperidol, chlorpromazine, thioridazine and clozapine, for 21 days elicited increased dopamine metabolism in frontal cortex of rat brain. Only clozapine failed to decrease the apparent firing rate of dopamine neurons in the striatum, as indexed by [homovanillic acid]/[dopamine]. These data support the hypotheses that frontal cortex dopamine neurons may be a common site for antipsychotic action while decreased release of dopamine in the striatum may be associated with the development of extrapyramidal side effects.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid metabolism
Animals
Chlorpromazine pharmacology
Corpus Striatum drug effects
Corpus Striatum metabolism
Frontal Lobe drug effects
Haloperidol pharmacology
Homovanillic Acid metabolism
Male
Rats
Rats, Inbred Strains
Thioridazine pharmacology
Time Factors
Antipsychotic Agents administration & dosage
Dopamine metabolism
Frontal Lobe metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 475
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 2905626
- Full Text :
- https://doi.org/10.1016/0006-8993(88)90630-0