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Enhancement of dopamine metabolism in rat brain frontal cortex: a common effect of chronically administered antipsychotic drugs.

Enhancement of dopamine metabolism in rat brain frontal cortex: a common effect of chronically administered antipsychotic drugs.

Authors :
Mefford IN
Roth KA
Agren H
Barchas JD
Source :
Brain research [Brain Res] 1988 Dec 20; Vol. 475 (2), pp. 380-4.
Publication Year :
1988

Abstract

Administration of 4 antipsychotic drugs, haloperidol, chlorpromazine, thioridazine and clozapine, for 21 days elicited increased dopamine metabolism in frontal cortex of rat brain. Only clozapine failed to decrease the apparent firing rate of dopamine neurons in the striatum, as indexed by [homovanillic acid]/[dopamine]. These data support the hypotheses that frontal cortex dopamine neurons may be a common site for antipsychotic action while decreased release of dopamine in the striatum may be associated with the development of extrapyramidal side effects.

Details

Language :
English
ISSN :
0006-8993
Volume :
475
Issue :
2
Database :
MEDLINE
Journal :
Brain research
Publication Type :
Academic Journal
Accession number :
2905626
Full Text :
https://doi.org/10.1016/0006-8993(88)90630-0