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Celiprolol and atenolol in angina--effects on left ventricular function.
Celiprolol and atenolol in angina--effects on left ventricular function.
- Source :
-
The Journal of international medical research [J Int Med Res] 1988; Vol. 16 Suppl 1, pp. 47A-51A. - Publication Year :
- 1988
-
Abstract
- Celiprolol, 400 mg once daily, and atenolol, 100 mg once daily, were compared in a double-blind placebo-controlled crossover study of 16 patients with stable angina. Both drugs reduced angina frequency and delayed the onset of ischaemia during exercise, although only celiprolol prolonged exercise time. Celiprolol produced less suppression of heart rate than atenolol during exercise, and atenolol, but not celiprolol, lowered resting and exercise cardiac output. Thus, the ancillary properties of celiprolol, including partial beta 2-adrenoceptor agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.
- Subjects :
- Adult
Aged
Angina Pectoris physiopathology
Angina Pectoris prevention & control
Celiprolol
Clinical Trials as Topic
Double-Blind Method
Female
Heart Function Tests
Heart Rate drug effects
Heart Ventricles drug effects
Heart Ventricles physiopathology
Humans
Male
Middle Aged
Physical Exertion
Adrenergic beta-Antagonists therapeutic use
Angina Pectoris drug therapy
Atenolol therapeutic use
Propanolamines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0605
- Volume :
- 16 Suppl 1
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 2906017