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Celiprolol and atenolol in angina--effects on left ventricular function.

Celiprolol and atenolol in angina--effects on left ventricular function.

Authors :
Dargie H
McLenachan JM
Wilson JT
Source :
The Journal of international medical research [J Int Med Res] 1988; Vol. 16 Suppl 1, pp. 47A-51A.
Publication Year :
1988

Abstract

Celiprolol, 400 mg once daily, and atenolol, 100 mg once daily, were compared in a double-blind placebo-controlled crossover study of 16 patients with stable angina. Both drugs reduced angina frequency and delayed the onset of ischaemia during exercise, although only celiprolol prolonged exercise time. Celiprolol produced less suppression of heart rate than atenolol during exercise, and atenolol, but not celiprolol, lowered resting and exercise cardiac output. Thus, the ancillary properties of celiprolol, including partial beta 2-adrenoceptor agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.

Details

Language :
English
ISSN :
0300-0605
Volume :
16 Suppl 1
Database :
MEDLINE
Journal :
The Journal of international medical research
Publication Type :
Academic Journal
Accession number :
2906017