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Loss of inhibition in sensorimotor networks in focal hand dystonia.
- Source :
-
NeuroImage. Clinical [Neuroimage Clin] 2017 Oct 13; Vol. 17, pp. 90-97. Date of Electronic Publication: 2017 Oct 13 (Print Publication: 2018). - Publication Year :
- 2017
-
Abstract
- Objective: To investigate GABA-ergic receptor density and associated brain functional and grey matter changes in focal hand dystonia (FHD).<br />Methods: 18 patients with FHD of the right hand and 18 age and gender matched healthy volunteers (HV) participated in this study. We measured the density of GABA-A receptors using [ <superscript>11</superscript> C] Flumazenil and perfusion using [ <superscript>15</superscript> O] H <subscript>2</subscript> O. Anatomical images were also used to measure grey matter volume with voxel-based morphometry (VBM).<br />Results: In FHD patients compared to HV, the vermis VI of the right cerebellum and the left sensorimotor cortex had a decrease of Flumazenil binding potential (FMZ-BP), whereas the striatum and the lateral cerebellum did not show significant change. Bilateral inferior prefrontal cortex had increased FMZ-BP and an increase of perfusion, which correlated negatively with disease duration. Only the left sensorimotor cortex showed a decrease of grey matter volume.<br />Interpretation: Impairments of GABAergic neurotransmission in the cerebellum and the sensorimotor cortical areas could explain different aspects of loss of inhibitory control in FHD, the former being involved in maladaptive plasticity, the latter in surround inhibition. Reorganization of the inferior prefrontal cortices, part of the associative network, might be compensatory for the loss of inhibitory control in sensorimotor circuits. These findings suggest that cerebellar and cerebral GABAergic abnormalities could play a role in the functional imbalance of striato-cerebello-cortical loops in dystonia.
- Subjects :
- Adult
Aged
Carbon Radioisotopes pharmacokinetics
Case-Control Studies
Cerebellum diagnostic imaging
Cerebellum drug effects
Cerebrovascular Circulation
Female
Flumazenil pharmacokinetics
GABA Modulators pharmacokinetics
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen Isotopes pharmacokinetics
Oxygen Radioisotopes pharmacokinetics
Positron-Emission Tomography
Prefrontal Cortex drug effects
Young Adult
Brain Mapping
Dystonic Disorders diagnostic imaging
Dystonic Disorders pathology
Neural Pathways diagnostic imaging
Prefrontal Cortex diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1582
- Volume :
- 17
- Database :
- MEDLINE
- Journal :
- NeuroImage. Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 29062685
- Full Text :
- https://doi.org/10.1016/j.nicl.2017.10.011