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Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Oct; Vol. 163 (6), pp. 785-788. Date of Electronic Publication: 2017 Oct 24. - Publication Year :
- 2017
-
Abstract
- The expression of Notch2, Numb, and Cas8 genes, whose protein products are involved in regulation of neurogenesis/neuroapoptosis processes, was studied in the relevant cerebral structures of male Wistar rats trained in a spatial habit. The formation of long-term spatial memory was found to be associated with the formation of a specific pattern of transcription activity of the studied genes in different brain structures. The maximum expression of Notch2 gene was found in the hippocampus and cerebellum, the maximum expression of Numb was detected in the prefrontal cortex and cerebellum, and the maximum expression of Cas8 was revealed in the prefrontal cortex of trained animals.
- Subjects :
- Animals
Brain Mapping
Caspase 8 metabolism
Cerebellum anatomy & histology
Gene Expression Regulation
Hippocampus anatomy & histology
Intracellular Signaling Peptides and Proteins metabolism
Male
Maze Learning physiology
Prefrontal Cortex anatomy & histology
Rats
Rats, Wistar
Receptor, Notch2 metabolism
Signal Transduction
Swimming psychology
Caspase 8 genetics
Cerebellum metabolism
Hippocampus metabolism
Intracellular Signaling Peptides and Proteins genetics
Memory, Long-Term physiology
Prefrontal Cortex metabolism
Receptor, Notch2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 163
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29063319
- Full Text :
- https://doi.org/10.1007/s10517-017-3903-y